xpression within the liver of ducks; (G) HO-1 gene of ducks; (G) HO-1 gene expression

xpression within the liver of ducks; (G) HO-1 gene of ducks; (G) HO-1 gene expression in the liver of ducks; (H) GCLC gene expression within the liver of ducks; (I) GCLM gene expression in the liver of ducks; (H) GCLC gene expression within the liver of ducks; (I) GCLM gene expression within the liver of ducks. Valuesin the liver of ducks. Values imply the mean suggests p 0.01. p 0.05, signifies p 0.01. expression imply the imply SEM, means p 0.05, SEM, means3.8. Expression of COX-2 Formulation Molecules inside the NLRP3 aspase-1 Signaling Pathway three.eight. Expression of Molecules in the NLRP3 aspase-1 Signaling Pathway As shown in Figure 8, compared together with the T0 group, the mRNA levels of NLRP3 inside the As ducks had been drastically enhanced afterT0 group, the mRNA levelsan increasing liver of shown in Figure eight, compared using the AFB1 administration and of NLRP3 within the liver TXNIP and IL-18 gene expression was observed within the T + AFB1 group. As extrend of of ducks had been substantially increased following AFB1 administration and an increas0 ing trend of TXNIP and IL-18 gene AFB1 group, dietary curcumin considerably group. As pected, in comparison with the T0 + expression was observed in the T0 + AFB1 decreased expected, inlevels on the genes the T0 + AFB1 group,IL-18 (p 0.01) in liver of ducksdethe mRNA comparison with NLRP3, TXNIP and dietary curcumin substantially in creased the mRNA levels with the 8A ). Furthermore, compared to the0.01) in liver of ducks the T500 + AFB1 group (Figure genes NLRP3, TXNIP and IL-18 (p T0 group, there was in the T500 + AFB1 groupin the gene expression of NLRP3 and IL-18 (p0 0.05); there was no significant lower (Figure 8A ). Furthermore, in comparison with the T group, having said that, no substantial reduce raise in TXNIP (p 0.05) gene expression(p the T500 + AFB1 there was a important within the gene expression of NLRP3 and IL-18 in 0.05); on the other hand, there was a significant increase in and caspase-1 have been drastically increasedT500theAFB1 group. the protein levels of NLRP3 TXNIP (p 0.05) gene expression in the in + liver group. the protein+levels of NLRP3 and caspase-1 have been significantly improved in to the T0 of ducks within the T0 AFB1 group compared together with the T0 group; whereas, compared the liver ofAFB1 group, it hadAFB1 group compared using the T0 group; whereas,caspase-1 protein + ducks inside the T0 + a considerable effect around the KDM2 medchemexpress decrease in NLRP3 and in comparison with the T0 + AFB1 group, it had aAFB1 group (Figure 8D ). A important decrease in caspase-1 expression inside the T500 + significant influence around the lower in NLRP3 and caspase-1 protein expression inside the T 0.05) was observed in the T500 A considerable compared caspaseprotein expression (p 500 + AFB1 group (Figure 8D ).+ AFB1 groupdecrease in with all the 1 protein expression (p 0.05) was observed in the T500 + AFB1 group compared with theFoods 2021, 10, 3086 PEER Overview Foods 2021, ten, x FOR10 of 19 12 ofT T00 group; whereas, there was a usually growing trend in NLRP3 protein expression (p there was a usually rising trend in NLRP3 protein expression (p 0.05). These final results indicated that dietary curcumin protected the liver against injury 0.05). These final results indicated that dietary curcumin protected against injury induced by AFB1 administration by inhibiting the NLRP3 aspase-1 signaling pathway. induced by AFB1 administration by inhibiting the NLRP3 aspase-1 signaling pathway.Figure eight. Expression of molecules in NLRP3 aspase-1 signaling way in liver of ducks exposed to AFB1 at 12 h. (A) TXNIP Figure eight. Ex