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HHS Public AccessAuthor manuscriptNature. Author manuscript; obtainable in PMC 2021 May possibly 02.Published in last edited kind as: Nature. 2020 October ; 586(7828): 29904. doi:10.1038/s41586-020-2774-y.Author Manuscript Author Manuscript Author Manuscript Writer ManuscriptTumoural activation of TLR3-SLIT2 axis in endothelium drives metastasisBernardo Tavora1, Tobias Mederer#1, Kai Wessel#1, Simon Ruffing1, Mahan Sadjadi1, Marc Missmahl1, Benjamin N. Ostendorf1, Xuhang Liu1, Ji-Young Kim1, Olav Olsen2, Alana L. Welm3, Hani Goodarzi4, Sohail F. Tavazoie1,1Laboratoryof Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New york, NY 10065, USA.2Laboratoryof Brain Advancement and Restore, The Rockefeller University, 1230 York Avenue, New york, NY 10065, USA. of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA. of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA. These authors contributed equally to this perform.3Department4Department#AbstractBlood vessels help tumours by giving nutrients and oxygen, when also acting as conduits for your dissemination of cancer1. Here we use mouse models of breast and lung cancer to investigate whether or not endothelial cells also have active `instructive’ roles during the dissemination of cancer. We purified genetically tagged endothelial ribosomes and their associated transcripts from extremely and poorly metastatic tumours. Deep sequencing uncovered that metastatic tumours inducedAuthor Information Reprints and Permissions Information is accessible at www.nature.com/reprints. Correspondence and requests for supplies ought to be addressed to S.F.T. ([email protected]).