Tumor properties of the new 2-R-7H-dibenzo[de,h]quinolin7-ones (2) have been investigated in vivo, in vitro, and in silico. The synthesized compounds exhibited high anti-inflammatory activity at dose 20 mg/kg i.p. within the models of exudative (histamine-induced) and immunogenic (concanavalin A-induced) inflammation. The derivatives 2b, 2d, 3b, and 3i had probably the most potent effects, which are comparable with these of indomethacin. All compounds had no cytotoxic impact on immortalized humane fibroblasts. Compounds 3j and 3k show moderate (IC50 = 21.three) antitumor activity on cervical cancer culture HeLa. Compound 3j also exhibited a weak antitumor impact on multiform glioblastoma and breast cancer cell cultures. Molecular docking data demonstrate that such molecules as 3j can potentially intercalate in to the binding internet site inside the DNA molecule similarly towards the reference antitumor drug doxorubicin.Author Contributions: Conceptualization, S.F.V., I.V.A. and T.G.T.; methodology, S.F.V., I.V.S. and D.S.B.; computer software, I.V.A. and D.S.B.; validation, S.F.V. and I.V.S.; formal evaluation, I.V.A. and T.G.T.; investigation, O.L.K., D.S.B. and I.V.S.; sources, S.F.V.; Rogaratinib In Vitro Information curation, S.F.V. and I.V.A.; writing– original draft preparation, S.F.V., I.V.S. and D.S.B.; writing–review and editing, I.V.A.; visualization, D.S.B.; supervision and project administration, S.F.V.; funding acquisition, S.F.V. All authors have read and agreed for the published version in the manuscript. Funding: Russian Foundation for Simple Study (grant no. 1630589). Institutional Review Board Statement: The study was carried out as outlined by the guidelines with the Declaration of Helsinki, and authorized by the Institutional Bio-Ethics Committee of N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch from the Russian Academy of Sciences (protocol code P-1-03.2020-14 and 18 March 2020 date of approval). Informed Consent Statement: Not applicable. Data Availability Statement: Information regarding synthesis, isolation and characterization are readily available upon request from S.V. Data related towards the biological activity studies is available from I.S. Acknowledgments: This perform was supported by the Russian Foundation for Standard Analysis (grant No. 1630589). Investigation at FSU is supported by the National Science Foundation (CHE-2102579). Authors dedicate this paper to J. Elguero in recognition of his numerous contributions to heterocyclic chemistry. Conflicts of Interest: The authors declare no conflict of interest. Sample Availability: Samples with the compounds may be out there from the authors but only with the permission on the Institute of 4-Methylumbelliferyl Dye Reagents Chemical Kinetics and Combustion.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is definitely an open access post distributed under the terms and circumstances of your Creative Commons Attribution (CC BY) license (licenses/by/ four.0/).Periodontal disease may be the topic of a public overall health difficulty, becoming a pathology that joins general circumstances. This pathology, also referred to as periodontitis, is definitely an infectious illness of the oral cavity, characterized by irreversible destruction from the tooth-supporting structures: Alveolar bone, periodontal ligament, and cementum . Periodontitis is one of the significant causes of tooth loss, which endangers the functions in the stomatognathic technique: Mastication, phonation, physiognomy, aesthetics, at the same time as self-confidence, self-esteem, and quality of life of sufferers [2,3]. As outlined by a 2016 survey fulfil.