Name :
S100B Protein
Description :
S100B, a calcium-binding protein of the EF-hand type exerts both intracellular and extracellular functions.The intracellular, and extracellular, roles of S100B are attractive therapeutic targets for the treatment of both cardiac and vascular disease.
Species :
Canine
Uniprotkb :
HEK293
Tag :
N-hFc
Synonyms :
S100 calcium-binding, S100-B, 100β, 100beta, NEF, Protein S100, S100
Construction :
Recombinant Canine S100B Protein is expressed from HEK293 with hFc tag at the N-Terminus. It contains Ser2-Glu92.[Accession |E2QTP3]
Protein Purity :
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight :
The protein has a predicted MW of 36.52 kDa. Due to glycosylation, the protein migrates to 40-45 kDa based on Tris-Bis PAGE result.
Endotoxin :
Less than 1EU per μg by the LAL method.
Formulatione :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage :
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background :
S100B, a calcium-binding protein of the EF-hand type exerts both intracellular and extracellular functions.The intracellular, and extracellular, roles of S100B are attractive therapeutic targets for the treatment of both cardiac and vascular disease.
References and Literature :
1. Tsoporis JN, et al. S100B: a multifunctional role in cardiovascular pathophysiology. Amino Acids. 2011 Oct;41(4):843-7. doi: 10.1007/s00726-010-0527-Epub 2010 Mar 4. PMID: 20204434.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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