Human ALK-1/ACVRL1 Protein 4235

Additional Information:
accession P37023|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundActivin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence.|molecular weightThe protein has a predicted MW of 11.5 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human ALK-1/ACVRL1 Protein 4235proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceActivin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence.Protein namesSerine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)Gene namesACVRL1,ACVRL1 ACVRLK1 ALK1Protein familyProtein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamMass9606DaFunctionType I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.Catalytic activityBINDING 208..216; /ligand=”ATP”; /ligand_id=”ChEBI:CHEBI:30616″; /evidence=”ECO:0000255|PROSITE-ProRule:PRU00159″; BINDING 229; /ligand=”ATP”; /ligand_id=”ChEBI:CHEBI:30616″; /evidence=”ECO:0000255|PROSITE-ProRule:PRU00159″Subellular locationCell membrane ; Single-pass type I membrane protein .StructureInteracts with TSC22D1/TSC-22.Target Relevance information above includes information from UniProt accession: P37023The UniProt Consortium|