Cynomolgus AXL Protein 3499

Additional Information:
accession A0A1D5Q330|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundAxl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.|molecular weightThe protein has a predicted MW of 46.3 kDa. Due to glycosylation, the protein migrates to 68-70 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Cynomolgus AXL Protein 3499proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceAxl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.Protein namesreceptor protein-tyrosine kinase (EC 2.7.10.1)Gene namesAXL,AXLProtein familyProtein kinase superfamily, CAMK Ser/Thr protein kinase familyMass9544DaCatalytic activityBINDING 567; /ligand=”ATP”; /ligand_id=”ChEBI:CHEBI:30616″; /evidence=”ECO:0000256|PROSITE-ProRule:PRU10141″; BINDING 677; /ligand=”Mg(2+)”; /ligand_id=”ChEBI:CHEBI:18420″; /evidence=”ECO:0000256|PIRSR:PIRSR000615-3″; BINDING 690; /ligand=”Mg(2+)”; /ligand_id=”ChEBI:CHEBI:18420″; /evidence=”ECO:0000256|PIRSR:PIRSR000615-3″Subellular locationMembrane ; Single-pass type I membrane protein .Target Relevance information above includes information from UniProt accession: A0A1D5Q330The UniProt Consortium|