Product Name :
Dacomitinib
Description:
Dacomitinib, also known as PF-299 and PF-00299804 ; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.
CAS:
1110813-31-4
Molecular Weight:
469.94
Formula:
C24H25ClFN5O2
Chemical Name:
(2E)-N-4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl-4-(piperidin-1-yl)but-2-enamide
Smiles :
COC1=CC2=NC=NC(NC3C=C(Cl)C(F)=CC=3)=C2C=C1NC(=O)/C=C/CN1CCCCC1
InChiKey:
LVXJQMNHJWSHET-AATRIKPKSA-N
InChi :
InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Oleandrin Technical Information
Shelf Life:
≥360 days if stored properly.Crizanlizumab Immunology/Inflammation
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35091362
Additional information:
Dacomitinib, also known as PF-299 and PF-00299804 ; or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.|Product information|CAS Number: 1110813-31-4|Molecular Weight: 469.94|Formula: C24H25ClFN5O2|Chemical Name: (2E)-N-4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl-4-(piperidin-1-yl)but-2-enamide|Smiles: COC1=CC2=NC=NC(NC3C=C(Cl)C(F)=CC=3)=C2C=C1NC(=O)/C=C/CN1CCCCC1|InChiKey: LVXJQMNHJWSHET-AATRIKPKSA-N|InChi: InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
