Product Name :
NH-3
Description:
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.
CAS:
447415-26-1
Molecular Weight:
473.52
Formula:
C28H27NO6
Chemical Name:
2-[4-(4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-(propan-2-yl)phenylmethyl)-3, 5-dimethylphenoxy]acetic acid
Smiles :
CC1C=C(C=C(C)C=1CC1C=C(C(C)C)C(O)=C(C=1)C#CC1C=CC(=CC=1)N(=O)=O)OCC(O)=O
InChiKey:
IXMROOKFPWGDGF-UHFFFAOYSA-N
InChi :
InChI=1S/C28H27NO6/c1-17(2)25-14-21(15-26-18(3)11-24(12-19(26)4)35-16-27(30)31)13-22(28(25)32)8-5-20-6-9-23(10-7-20)29(33)34/h6-7,9-14,17,32H,15-16H2,1-4H3,(H,30,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.KH-3 Epigenetics
Shelf Life:
≥12 months if stored properly.Cimetidine Biological Activity
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33007509
Additional information:
NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.|Product information|CAS Number: 447415-26-1|Molecular Weight: 473.52|Formula: C28H27NO6|Chemical Name: 2-[4-(4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-(propan-2-yl)phenylmethyl)-3, 5-dimethylphenoxy]acetic acid|Smiles: CC1C=C(C=C(C)C=1CC1C=C(C(C)C)C(O)=C(C=1)C#CC1C=CC(=CC=1)N(=O)=O)OCC(O)=O|InChiKey: IXMROOKFPWGDGF-UHFFFAOYSA-N|InChi: InChI=1S/C28H27NO6/c1-17(2)25-14-21(15-26-18(3)11-24(12-19(26)4)35-16-27(30)31)13-22(28(25)32)8-5-20-6-9-23(10-7-20)29(33)34/h6-7,9-14,17,32H,15-16H2,1-4H3,(H,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose.|Products are for research use only. Not for human use.|
