Nthetic Model of Beta-Thalassemia

High intensity interval training (HIT), a training
Nthetic Model of Beta-Thalassemia
High intensity interval training (HIT), a training modality that alternates between brief repeated bursts of intense exercise and periods of active rest, improves several clinically relevant outcomes. Specifically, in both healthy and clinical populations, HIT improves VO2peak, exercise 1480666 performance, cardiovascular function, and markers of oxidative capacity in skeletal muscle [1]. HIT has also recently been reported to reduce systemic inflammation in both coronary intervention patients [2] and individuals with metabolic syndrome [3]. These physiological benefits can be achieved in less time and with less total exercise energy expenditure (i.e. exercise volume) than traditional endurance training (ET) [4,5]. However, while some evidence may suggest it is more enjoyable than ET [6], HIT is typically associated with near maximal or supramaximal intensities. These intensities Title Loaded From File represent a potential threat to theadoption of HIT by the general population as high intensity exercise is typically associated with negative feelings and poor exercise adherence [7], particularly in overweight/obese populations [8]. The safety of higher intensity protocols (i.e., supramaximal intervals) for populations with cardiovascular risk or disease has also been questioned [9]. Accordingly, there is a need for studies designed to determine whether reductions in the intensity of HIT that also result in decreases in exercise volume (i.e. decreases in the 18204824 energy expenditure associated with exercise), result in a loss of physiological adaptation such as improved aerobic capacity, skeletal muscle oxidative capacity, cardiovascular function, inflammatory response, etc. These studies are important as low intensity/low volume HIT would be expected to elicit less negative feelings and safety concerns typically associated with high intensity exercise [1,9]. While interval duration has been examined in cardiac patients [10] and both interval duration [11] and trainingInterval Training in Overweight/Obese Menfrequency [12] have been studied in young healthy adults, the impact of reducing both interval intensity and training volume is unknown. While recent evidence suggests that reduced-exertion HIT can result in important physiological adaptations [13], the question of how these improvements compare with those elicited by high intensity, high volume training programs remain. Esults on radiosensitivity in A549 cells, the mechanisms need to be Therefore, the purpose of this study was to compare the physiological adaptations resulting from regular performance of a high intensity/high volume (HI) interval training protocol to adaptations resulting from a low intensity/low volume (LO) interval training protocol. Changes in skeletal muscle oxidative capacity, aerobic capacity, exercise performance, peak O2 pulse, inflammation status, and perceived tolerability where examined in overweight/obese individuals. Specifically, we examined the above variables before and after 3 weeks of interval training using a 1minute on, 1-minute off protocol (adapted from Hood et al. [14]) at an interval intensity of either 100 (HI) or 70 (LO) of peak aerobic power. We hypothesized that increases in all measures of muscle oxidative capacity and aerobic function would be greater following HI than LO training. We also hypothesized that improvements in inflammatory status would be greatest in the HI group but that overall perceived tolerability would be highest following LO.Table 1. Participant Characteristics.LO Pre N Age (yrs.) Heig.High intensity interval training (HIT), a training
Nthetic Model of Beta-Thalassemia
High intensity interval training (HIT), a training modality that alternates between brief repeated bursts of intense exercise and periods of active rest, improves several clinically relevant outcomes. Specifically, in both healthy and clinical populations, HIT improves VO2peak, exercise 1480666 performance, cardiovascular function, and markers of oxidative capacity in skeletal muscle [1]. HIT has also recently been reported to reduce systemic inflammation in both coronary intervention patients [2] and individuals with metabolic syndrome [3]. These physiological benefits can be achieved in less time and with less total exercise energy expenditure (i.e. exercise volume) than traditional endurance training (ET) [4,5]. However, while some evidence may suggest it is more enjoyable than ET [6], HIT is typically associated with near maximal or supramaximal intensities. These intensities represent a potential threat to theadoption of HIT by the general population as high intensity exercise is typically associated with negative feelings and poor exercise adherence [7], particularly in overweight/obese populations [8]. The safety of higher intensity protocols (i.e., supramaximal intervals) for populations with cardiovascular risk or disease has also been questioned [9]. Accordingly, there is a need for studies designed to determine whether reductions in the intensity of HIT that also result in decreases in exercise volume (i.e. decreases in the 18204824 energy expenditure associated with exercise), result in a loss of physiological adaptation such as improved aerobic capacity, skeletal muscle oxidative capacity, cardiovascular function, inflammatory response, etc. These studies are important as low intensity/low volume HIT would be expected to elicit less negative feelings and safety concerns typically associated with high intensity exercise [1,9]. While interval duration has been examined in cardiac patients [10] and both interval duration [11] and trainingInterval Training in Overweight/Obese Menfrequency [12] have been studied in young healthy adults, the impact of reducing both interval intensity and training volume is unknown. While recent evidence suggests that reduced-exertion HIT can result in important physiological adaptations [13], the question of how these improvements compare with those elicited by high intensity, high volume training programs remain. Therefore, the purpose of this study was to compare the physiological adaptations resulting from regular performance of a high intensity/high volume (HI) interval training protocol to adaptations resulting from a low intensity/low volume (LO) interval training protocol. Changes in skeletal muscle oxidative capacity, aerobic capacity, exercise performance, peak O2 pulse, inflammation status, and perceived tolerability where examined in overweight/obese individuals. Specifically, we examined the above variables before and after 3 weeks of interval training using a 1minute on, 1-minute off protocol (adapted from Hood et al. [14]) at an interval intensity of either 100 (HI) or 70 (LO) of peak aerobic power. We hypothesized that increases in all measures of muscle oxidative capacity and aerobic function would be greater following HI than LO training. We also hypothesized that improvements in inflammatory status would be greatest in the HI group but that overall perceived tolerability would be highest following LO.Table 1. Participant Characteristics.LO Pre N Age (yrs.) Heig.